FSHR SNP Analysis in Mexican Populations

To compare the allelic and genotype frequency of the FSHR SNPs found in the above described groups with those from an open Mexican population, a third group of data (SIGMA cohort) from a large database genotyped using the Illumina OMNI 2.5 array was analyzed. This reference sample was conformed by 8182 Mexican mestizo subjects participants in the Slim Initiative in Genomic Medicine from the Americas (SIGMA) Type 2 Diabetes Consortium [35 (link)] [3515 (43%) male and 4667 (57%) female; 4366 (53%) non-diabetic and 3848 (47%) subjects with type 2 diabetes (T2D), all exhibiting Native American and European ancestry as determined by Principal Components Analysis [36 (link)]]. Details on the selection criteria, quality control procedure, and estimation of Native American and European ancestry proportions have been reported elsewhere [35 (link)]. In our secondary analysis of this reference database, information related with reproductive events such as age at menarche and menopause, and number of pregnancies in a subset of 520 women (aged 34 to 89 years, median 52 years) were extracted from this database (UIDS cohort; [35 (link)]) and analyzed for potential associations with the FSHR SNPs studied.

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García-Jiménez G., Zariñán T., Rodríguez-Valentín R., Mejía-Domínguez N.R., Gutiérrez-Sagal R., Hernández-Montes G., Tovar A., Arechavaleta-Velasco F., Canto P., Granados J., Moreno-Macias H., Tusié-Luna T., Pellicer A, & Ulloa-Aguirre A. (2018). Frequency of the T307A, N680S, and -29G>A single-nucleotide polymorphisms in the follicle-stimulating hormone receptor in Mexican subjects of Hispanic ancestry. Reproductive Biology and Endocrinology : RB&E, 16, 100.

Publication 2018

OMNI 2.5 array

Allelic European Female Fshr Male Menarche Menopause Native american Reproductive Snps Type 2 diabetes Women

Corresponding Organization :

Other organizations : Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Universidad Nacional Autónoma de México, Instituto Nacional de Salud Pública, Universidad Autónoma Metropolitana

Top 5 similar protocols

Variable analysis

independent variables

FSHR SNPs

dependent variables

Allelic frequency
Genotype frequency

control variables

Mexican mestizo subjects participants in the Slim Initiative in Genomic Medicine from the Americas (SIGMA) Type 2 Diabetes Consortium
Non-diabetic and type 2 diabetes (T2D) subjects
Native American and European ancestry proportions
Age at menarche and menopause
Number of pregnancies

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