PET Imaging of [11C]-(+)-PHNO Synthesis and Analysis
[11C]-(+]-PHNO was synthesized as described earlier31 (link). Quality control was in accordance with European Pharmacopoeia. PET images were acquired on a GE Advance scanner (General Electric Medical Systems, Milwaukee, WI). Emission data were acquired over 90 min after bolus-injection of 309 [81] MBq (mean [SD]) [11C]-(+)-PHNO. Raw data were reconstructed by filtered-back projection to yield dynamic images in 15 consecutive one-minute frames followed by 15 five-minute frames. With exception of two patients who chose to terminate their participation early, all subjects underwent T1 and proton density (PD) weighted 3 T magnetic resonance (MR) imaging (see Supplemental Material).
Weidenauer A., Bauer M., Sauerzopf U., Bartova L., Nics L., Pfaff S., Philippe C., Berroterán-Infante N., Pichler V., Meyer B.M., Rabl U., Sezen P., Cumming P., Stimpfl T., Sitte H.H., Lanzenberger R., Mossaheb N., Zimprich A., Rusjan P., Dorffner G., Mitterhauser M., Hacker M., Pezawas L., Kasper S., Wadsak W., Praschak-Rieder N, & Willeit M. (2020). On the relationship of first-episode psychosis to the amphetamine-sensitized state: a dopamine D2/3 receptor agonist radioligand study. Translational Psychiatry, 10, 2.
Dynamic images in 15 consecutive one-minute frames followed by 15 five-minute frames
control variables
Quality control in accordance with European Pharmacopoeia
T1 and proton density (PD) weighted 3 T magnetic resonance (MR) imaging
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