Biocompatible Column for Concurrent Micro-PET/SPECT

Example 1

FIG. 1 shows the biocompatible column 1 for concurrent micro-PET or micro-SPECT of the first cell culture 6a and the second cell culture 6b, which are both MTS. The column comprises the inlet 2, the axially oriented perfusion chamber 3 and the outlet 4. Both the inlet 2 and the outlet 4 are fluidly connected to the perfusion chamber 3. The perfusion chamber 3 comprises porous solid phase formed by four sponges, 7c, 7d, 7a, 7b, made of a biopolymer and which were pre-cut to fit into perfusion chamber 3. The liquid phase 5 consisting of growth medium extends from the inlet 2 through sponges 7c, 7d, 7a, 7b to the outlet 4. Sponges 7a and 7b have recesses 8a and 8b, respectively. The first cell culture 6a is located within recess 8a being in contact with sponge 7a, and the second cell culture 6b is located within recess 8b being in contact with sponge 7b. Sponges 7c and 7d neither have a recess nor a cell culture. The first cell culture 6a and the second cell culture 6b our separated from each other by sponge 7a. The column 1 further has one filter 50 adjacent to the inlet 2 and another filter 50 adjacent to sterile filter 51, which is adjacent to the outlet 4.