[18F]RO948-PET was performed on a digital GE Discovery MI scanner, 70–90 min post-injection. Standardized uptake value ratio (SUVR) images were created using the inferior cerebellar cortex as reference region19 (link). Complete PET details are described elsewhere20 (link).
In order to capture brain areas affected by tau deposition over the course of AD, three composite FreeSurfer-based regions-of-interest (ROI) were created according to the Braak tau pathology staging scheme21 (link). These include region I-II (the entorhinal cortex and hippocampus), region III-IV (parahippocampal cortices, fusiform cortices, amygdala, as well as the inferior and the middle temporal cortices), and region V-VI (widespread neocortical areas)22 (link). In a secondary analysis, regional associations between MBI-C total scores and [18F]RO948 SUVR were assessed using voxel-wise multiple regression models, including age, sex, education, and white matter volume as covariates, as implemented in SPM12 (https://www.fil.ion.ucl.ac.uk/spm/software/spm12/ ).
In order to capture brain areas affected by tau deposition over the course of AD, three composite FreeSurfer-based regions-of-interest (ROI) were created according to the Braak tau pathology staging scheme21 (link). These include region I-II (the entorhinal cortex and hippocampus), region III-IV (parahippocampal cortices, fusiform cortices, amygdala, as well as the inferior and the middle temporal cortices), and region V-VI (widespread neocortical areas)22 (link). In a secondary analysis, regional associations between MBI-C total scores and [18F]RO948 SUVR were assessed using voxel-wise multiple regression models, including age, sex, education, and white matter volume as covariates, as implemented in SPM12 (
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