NF-κB Gene Expression Analysis

Gene expression analysis of a predefined group of 200 NF-κB-regulated genes (Broad Institute curated HALLMARK NF-κB gene-set [39 (link)]) was evaluated via mRNA Sequencing (Illumina) on RNA isolated from whole blood (PAXgene Blood mRNA Kit, PreAnalytix).

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Finanger E., Vandenborne K., Finkel R.S., Lee Sweeney H., Tennekoon G., Yum S., Mancini M., Bista P., Nichols A., Liu H., Fretzen A, & Donovan J.M. (2019). Phase 1 Study of Edasalonexent (CAT-1004), an Oral NF-κB Inhibitor, in Pediatric Patients with Duchenne Muscular Dystrophy. Journal of Neuromuscular Diseases, 6(1), 43-54.

Publication 2018

PAXgene Blood mRNA Kit

Blood Gene Gene expression analysis Mrna Nf κb

Corresponding Organization : Catabasis Pharmaceuticals (United States)

Other organizations : Oregon Health & Science University, University of Florida Health, Nemours Children's Clinic, Children's Hospital of Philadelphia

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Gene expression analysis of a predefined group of 200 NF-κB-regulated genes (Broad Institute curated HALLMARK NF-κB gene-set)

control variables

Whole blood samples (PAXgene Blood mRNA Kit, PreAnalytix)

controls

None explicitly mentioned

Annotations

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