Hepatitis B Vaccine Response in Healthy Chinese Adults

The present study was conducted in a Chinese Han population. A cohort of 12 healthy adults was voluntarily recruited from the community health service center of Dalang, Dongguan (Table 4).The HB vaccine (20 μg) was administered via intramuscular injection of the deltoid according to a 0-, 1-, and 6-month standard schedule (recombinant hepatitis B vaccine, Engerix-B, GlaxoSmithKline, Brentford, UK) [30 (link)].None of the subjects had a history of infection with HBV, hepatitis C virus or human immunodeficiency virus, and none were immunodeficient. There were no smokers among the study subjects. We administered a booster HB vaccine via intramuscular injection in the upper arm deltoid and collected 25 mL peripheral venous blood at baseline before and after vaccination on days 7 and 14.Table 4

Demographic characteristics of study cohort

N	12
Gender (M/F)	6/6
Age (years)	28.83 ± 3.95
BMI	21.81 ± 3.54

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Xu X., Li Y., Liang Y., Yin M., Yu Z., Zhang Y., Huang L, & Ni J. (2018). MiR-18a and miR-17 are positively correlated with circulating PD-1+ICOS+ follicular helper T cells after hepatitis B vaccination in a chinese population. BMC Immunology, 19, 25.

Publication 2018

Engerix-B

Adults Blood Booster vaccine Chinese Deltoid Engerix b Hepatitis b vaccine Hepatitis c virus Human immunodeficiency virus Immunodeficient Infection Intramuscular injection Upper arm Vaccination Vaccine Venous

Corresponding Organization :

Other organizations : Guangdong Medical College

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Variable analysis

independent variables

Time points of blood collection (baseline, day 7, day 14)

dependent variables

Immune response to hepatitis B vaccine

control variables

Gender
No history of HBV, HCV, or HIV infection
No immunodeficiency
No smoking

controls

Positive control: Hepatitis B vaccine administered via intramuscular injection according to a 0-, 1-, and 6-month standard schedule

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