ADMET Profiling of Chrysin and Lamivudine

The drug-likeness analysis was performed by admetSAR and SwissADME to confirm any cytotoxicity produced by ligands in humans. Several pharmacokinetics properties such as absorption, distribution, metabolism, excretion and toxicity (ADMET) of the tested compound chrysin and the positive control lamivudine were measured with the web tools admetSAR [37 (link)] and SwissADME [38 (link)]. The physicochemical properties were also studied with the help of these servers.

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Bhat S.A., Hasan S.K., Parray Z.A., Siddiqui Z.I., Ansari S., Anwer A., Khan S., Amir F., Mehmankhah M., Islam A., Minuchehr Z, & Kazim S.N. (2023). Potential antiviral activities of chrysin against hepatitis B virus. Gut Pathogens, 15, 11.

Publication 2023

Admet Chrysin Cytotoxicity Drug Humans Lamivudine Ligands Metabolism Pharmacokinetics

Corresponding Organization :

Other organizations : Jamia Millia Islamia, National Institute of Genetic Engineering and Biotechnology

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Variable analysis

independent variables

Chrysin
Lamivudine

dependent variables

Absorption
Distribution
Metabolism
Excretion
Toxicity (ADMET)
Physicochemical properties

control variables

Not explicitly mentioned

controls

Positive control: lamivudine
Negative control: Not mentioned

Annotations

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