[Methyl- 3 H]-thymidine (20 Ci/mmol) (cat. no. NET027X) was obtained from PerkinElmer (Boston, MA, USA). 1-Oleoyl-lysophosphatidic acid (LPA) was purchased from either Santa Cruz Biotechnology (Dallas, TX, USA, cat. no. sc-222720) or Sigma-Aldrich (St. Louis, MO, USA, cat. no. L-7260). NVP-TAE684 (TAE684) (cat. no. HY-10192) and alectinib (also termed as CH5424802) (cat. no. HY-13011A) were from MedChem Express Europe (Sollentuna, Sweden). Carbachol chloride (CCh) was from Sigma-Aldrich (cat. no. C-4382). Human recombinant EGF (hEGF) (cat. no. 72528) and human recombinant IGF-1 (cat. no. 11343316) were from Cell Signaling Technology (Beverly, MA, USA) and Immuno Tools GmbH (Friesoythe, Germany), respectively. Tyrphostin AG1478 (AG1478) (cat. no. 1276/10) and PD98059 (cat no. 1213) were obtained from Tocris Bioscience (Bristol, UK). Bordetella pertussis toxin (PTX) (cat. no. PHZ1174) was from Gibco/Life Technologies, (Frederick, MD, USA).