Cell Treatments with Pharmacological Compounds

Cells were treated with the following drugs at concentrations and times as indicated in the figure legends: Cycloheximide (Sigma-Aldrich, C7698), PP242 (Tocris 4257), Thapsigargin (Cayman Chemical Company 10522), Bafilomycin A (Sigma-Aldrich, B1793), Rucaparib (Selleck Chemicals, S1098), Olaparib (Cellagen Technologies, C2228-5s) BMN637 was a gift from Alan Ashworth^{43 (link)}, is commercially available from Selleck Chemicals (S7048), menadione (Sigma-Aldrich, M5625), N-acetyl cysteine (Sigma-Aldrich, A7250).

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Goldsmith J., Marsh T., Asthana S., Leidal A.M., Suresh D., Olshen A, & Debnath J. (2020). Ribosome profiling reveals a functional role for autophagy in mRNA translational control. Communications Biology, 3, 388.

Publication 2020

Cycloheximide PP242 Thapsigargin Bafilomycin A Rucaparib menadione N-acetyl cysteine

Bafilomycin a Cayman Cells Cycloheximide Drugs Menadione N acetyl cysteine Olaparib Pp242 Rucaparib Thapsigargin

Corresponding Organization :

Other organizations : University of California, San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center

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Variable analysis

independent variables

Cycloheximide (Sigma-Aldrich, C7698)
PP242 (Tocris 4257)
Thapsigargin (Cayman Chemical Company 10522)
Bafilomycin A (Sigma-Aldrich, B1793)
Rucaparib (Selleck Chemicals, S1098)
Olaparib (Cellagen Technologies, C2228-5s)
BMN637 (Selleck Chemicals, S7048)
Menadione (Sigma-Aldrich, M5625)
N-acetyl cysteine (Sigma-Aldrich, A7250)

dependent variables

Not explicitly mentioned

control variables

Not explicitly mentioned

controls

BMN637 was a gift from Alan Ashworth

Annotations

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