Five priority outcomes are: 1) reproduction and pregnancy complications (e.g. abnormal pregnancies, premature birth, unbalanced sex ratio, and miscarriage), 2) congenital anomalies (ventricular septal defects, hypospadias, undescended testis, cleft lip/cleft palate, and chromosomal anomalies), 3) neuropsychiatric disorders (autism spectrum disorders, learning disorders, and attention-deficit hyperactivity disorder), 4) allergies and immune system deficiencies (asthma, atopic dermatitis, and food allergies), 5) metabolism and endocrine system disorders (impaired glucose tolerance, obesity, impact on reproductive organs, impaired genital formations, and sexual differentiation disorder). However, hundred thousand is not enough to analyze the association between environmental exposures and cancers. JECS collects cancer information in order to contribute future international pooled analysis, e.g. International Childhood Cancer Cohort Consortium (I4C) [6 (link)].
From the JECS cohort, a sub-cohort with the size of 5,000 will be extracted. In that sub-cohort extended outcome measurements are planned, for instance, clinical analysis of blood samples from children; face to face interviews by medical staffs to evaluate neurological development; and medical examination.
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