A complete description of the genetic ancestry of the PING sample is presented elsewhere (Akshoomoff et al., 2014 (link); Fjell, et al., 2012 ). Briefly, saliva samples were analyzed in the Scripps Translational Research Institute (STRI). Genomic DNA was genotyped with Illumina Human660W-Quad BeadChip and replication and quality control filters (sample call rate >99, call rates >95%, minor allele frequency >5%) were performed (Bakken, et al., 2012 ). A supervised clustering approach implemented in the ADMIXTURE software was used to assess genetic ancestry and admixture proportions in the PING participants (Alexander & Lange, 2011 (link)). Through this approach, a GAF was developed for each participant, representing the proportion of ancestral descent for each of six major continental populations: African, Central Asian, East Asian, European, Native American and Oceanic.
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Genetic Ancestry and Admixture Analysis
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A genetic
African
Central asian
Continental populations
East asian
European
Genetic
Genomic
Native american
Replication
Saliva
Corresponding Organization : Columbia University
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Variable analysis
independent variables
- Genetic ancestry and admixture proportions in the PING participants
- Proportion of ancestral descent for each of six major continental populations: African, Central Asian, East Asian, European, Native American and Oceanic
- Sample call rate >99, call rates >95%, minor allele frequency >5%
- None specified
- None specified
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