A subcohort of LRHF task rats was treated for four weeks while resting with a selective NK1RA (L732,138, Tocris Bioscience, R&D, Minneapolis, MN) at 5 mg/kg body weight in 50 µl of 95% ethanol in saline (dose determined from[20 ,21 (link)]). This dose was injected, i.p., 3x/week during the four week rest period. Subcohorts of FRC rats were either left untreated, or were treated for four weeks with the NK1RA drug or its vehicle (50 µl of 95% ethanol, i.p.) at matched time points as treated LRHF rats.
Protocol detail
NK1 Receptor Antagonist Treatment in LRHF Rats
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Other organizations : Temple University
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Variable analysis
independent variables
- Treatment with a selective NK1RA (L732,138) at 5 mg/kg body weight in 50 µl of 95% ethanol in saline
- Treatment duration of four weeks
- Not explicitly mentioned
- Subcohorts of FRC rats were either left untreated, or were treated for four weeks with the NK1RA drug or its vehicle (50 µl of 95% ethanol, i.p.) at matched time points as treated LRHF rats
- Positive control: FRC rats treated with the NK1RA drug
- Negative control: FRC rats left untreated
- Vehicle control: FRC rats treated with the NK1RA drug vehicle (50 µl of 95% ethanol, i.p.)
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