Health-related QOL was measured using the EuroQol 5-dimension (EQ-5D) instrument [39 (link)]. EQ-5D was developed as a non-disease specific standardized instrument, which could be used to complement existing health-related QOL measure [40 (link), 41 (link)]. It comprises five dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. Each dimension has three grades (no problems, some problems, and extreme problems), which generates a single index value for each health state. These values are numbers on a scale where 1 refers to full health and 0 refers to death.
Pain intensity and interference were measured using the Brief Pain Inventory (BPI) [42 (link), 43 (link)]. BPI comprises four pain intensity and seven pain interference items. These items are rated using a scale of 0–10, where 0 = no pain and 10 = worst possible pain. Based on the values obtained, individual pain intensity and interference scores were evaluated by calculating the mean. The validation and clinical utility of BPI has been evaluated for several disorders [44 (link)–46 (link)].