For complete details of all the experimental procedures, see
Neuroprotective Effects of Epicatechin in Intracerebral Hemorrhage
For complete details of all the experimental procedures, see
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Corresponding Organization : Johns Hopkins University
Protocol cited in 22 other protocols
Variable analysis
- Vehicle (sterilized water; Hospira, Chicago, IL)
- 5 mg/kg EC (Sigma, St. Louis, MO)
- 15 mg/kg EC (Sigma, St. Louis, MO)
- 45 mg/kg EC (Sigma, St. Louis, MO)
- Neurologic deficit score (24-point system)
- Time of EC administration (3 h after ICH and then every 24 h thereafter for 72 h)
- Route of administration (gavage)
- Purity and stability of EC (characterized in Fig. S1)
- Exclusion criteria (neurologic deficit scores greater than 20 or less than 3)
- Studies showing that one oral dose of EC (30 mg/kg) can cross the BBB and provide marked neuroprotection in β-amyloid-, N-methyl-D-aspartate (NMDA)-, and ischemia-induced brain injury
- Vehicle (sterilized water; Hospira, Chicago, IL)
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