Hypergravity Exposure in Mice

Unanesthetized mice were placed into a rodent holder (Kent Scientific, Torrington, CT, USA), which was placed on a motion platform (SK-L180-Pro, Scilogex, CT, USA). The platform was set to a frequency of 480 cycles per minute and Gz ± 3.0 m/s² for 1 h per day (morning 9–11 a.m.) for 8 consecutive days, as previously described (Adams 2009 [7 (link)]). The WT and db/db control groups were also placed in the rodent holder for 1 h per day for 8 consecutive days, but did not receive pGz treatment.

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Uryash A., Umlas J., Mijares A., Adams J.A, & Lopez J.R. (2023). Enhancing Muscle Intracellular Ca2+ Homeostasis and Glucose Uptake: Passive Pulsatile Shear Stress Treatment in Type 2 Diabetes. Biomedicines, 11(10), 2596.

Publication 2023

rodent holder SK-L180-Pro

Mice Rodent

Corresponding Organization : Mount Sinai Medical Center

Other organizations : Instituto Venezolano de Investigaciones Científicas

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Variable analysis

independent variables

Gz ± 3.0 m/s^2 (gravity acceleration) at a frequency of 480 cycles per minute for 1 h per day for 8 consecutive days

dependent variables

Not explicitly mentioned

control variables

Placement of WT and db/db mice into the rodent holder for 1 h per day for 8 consecutive days without receiving pGz treatment

controls

Positive control: WT (wild-type) mice
Negative control: db/db mice

Annotations

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