There were three PET scanners used in the study. Cohort-1 patients were all imaged on one of two General Electric (GE) Discovery STE PET/CT scanners [33 (link)], with identical reconstruction parameters, where each test-retest study was acquired on the same scanner. In addition to the recommended PET scanner calibration [32 (link)], the two scanners were cross-calibrated and quantitative performance was monitored with NIST-traceable reference sources to ensure similar quantitative accuracy [34 (link), 35 (link)].
Most cohort-2 patients (15) were imaged on the same PET/CT scanner in serial studies. However, due to the addition of the GE Discovery STE PET/CT scanners at our center, thirteen cohort-2 patients were initially imaged on a GE Advance PET scanner [36 (link)] and underwent the second scan on a Discovery scanner. We have shown that our calibration and cross-calibration procedures and identical acquisition and reconstruction protocols provide test-retest accuracy comparable to a well-calibrated single scanner [37 (link)].
Most cohort-2 patients (15) were imaged on the same PET/CT scanner in serial studies. However, due to the addition of the GE Discovery STE PET/CT scanners at our center, thirteen cohort-2 patients were initially imaged on a GE Advance PET scanner [36 (link)] and underwent the second scan on a Discovery scanner. We have shown that our calibration and cross-calibration procedures and identical acquisition and reconstruction protocols provide test-retest accuracy comparable to a well-calibrated single scanner [37 (link)].
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