Perioperative Glucose Variability in Cardiac Surgery

We retrieved BG data from CGM serially every 5 min and placed to group 1) preoperative period (Preoperative night: 6 pm–6 am of the day before surgery), 2) the morning day of surgery (morning of operation day: 6–8 am), 3) intraoperative period before CPB (Pre CPB), 4) CPB period (In CPB), 5) post CPB period (Post CPB: after off-CPB time to end of the operation), 6) postoperative period the day of surgery (POD 0: 6 pm–12 pm day of surgery), 7) postoperative period day 1 (POD1: after midnight of the day of surgery to midnight of another day), 8) postoperative period day 2 (POD2: after midnight of POD1 to midnight of another day). Overall perioperative period (Perioperative period) was counted from 6 pm of the day before surgery to midnight of POD2. All BG values from CGM regard to nine periods were analyzed into a mean with a 95% confidence interval.
GV measure in the present study was standard deviation (SD) calculated by using 5-mi interval of BG levels from CGM. SD was calculated in terms of nine group periods.
Additionally, we retrieved BG data from POCT-glucose to summarize events of hypoglycemia (<70 mg/dL), hyperglycemia (>180 mg/dL), and displayed box plots in a timeline with labeling administrations of liraglutide.

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Sindhvananda W., Poopuangpairoj W., Jaiprasat T, & Ongcharit P. (2023). Comparison of Glucose Control by Added Liraglutide to Only Insulin Infusion in Diabetic Patient Undergoing Cardiac Surgery: A Preliminary Randomized-Controlled Trial. Annals of Cardiac Anaesthesia, 26(1), 63-71.

Publication 2023

Day surgery Glucose Hyperglycemia Hypoglycemia Liraglutide Surgery Timeline

Corresponding Organization : Chulalongkorn University

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Variable analysis

independent variables

Perioperative period (6 pm of the day before surgery to midnight of POD2)

dependent variables

Mean blood glucose levels with 95% confidence interval
Standard deviation (SD) of blood glucose levels
Incidence of hypoglycemia (<70 mg/dL)
Incidence of hyperglycemia (>180 mg/dL)

control variables

Collected blood glucose data serially every 5 minutes from CGM
Divided the perioperative period into 9 distinct time periods: preoperative night, morning of surgery, pre-CPB, during CPB, post-CPB, POD0, POD1, POD2

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