Synthesis of Novel Hydrazide-Based Indolinones

Yellow powder (yield 49%); melt. pt. > 300 °C; ¹H NMR (400 MHz, DMSO-d₆) δ ppm: 2.07 (s, 3H, Acetamide Methyl), 3.21, 3.24 (s, 3H, N-Methyl), 7.14–7.23 (m, 2H, Ar. Proton), 7.43–7.67 (m, 10H, Ar. Proton), 10.20 (s, 1H, Acetamide NH), 14.26 (s, 1H, Hydrazide NH); ¹³C NMR (101MHz, DMSO-d₆) δ ppm: 24.51 (Acetamide Methyl), 26.17 (N-Methyl), 110.44, 119.11, 119.46, 121.00, 121.32, 123.73, 128.20, 130.04, 130.20, 132.69, 134.91, 136.69, 138.56, 141.87, 144.47, 154.96, 155.59, 155.68 (Hydrazide Carbonyl), 161.28 (Indolin-2-one Carbonyl), 169.42 (Acetamide Carbonyl); anal. calcd. for C₂₆H₂₀ClN₇O₃ (513.94 g/mol): C, 60.76; H, 3.92; N, 19.08; practical C, 60.73; H, 3.91; N, 19.11.

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Elsawi A.E., Shahin M.I., Elbendary H.A., Al-Warhi T., Hassan F.E, & Eldehna W.M. (2024). 1,2,4-Triazole-Tethered Indolinones as New Cancer-Fighting Small Molecules Targeting VEGFR-2: Synthesis, Biological Evaluations and Molecular Docking. Pharmaceuticals, 17(1), 81.

Publication 2024

Corresponding Organization : Kafrelsheikh University

Other organizations : Ain Shams University, Princess Nourah bint Abdulrahman University, Cairo University

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Variable analysis

independent variables

Not explicitly mentioned

dependent variables

Yield (49%)
Melting point (> 300 °C)
1H NMR spectrum
13C NMR spectrum
Elemental analysis (C, H, N)

control variables

Not explicitly mentioned

controls

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