Maternal Malaria Assessment in Pregnancy

Maternal malaria parasitemia was assessed every 4 weeks throughout pregnancy, beginning at enrollment. The presence of malaria parasites in maternal peripheral blood was evaluated using LAMP kits (Eiken Chemical), as previously described (27 (link), 28 (link)). LAMP assays were batch analyzed at the end of the trial and were not used to inform treatment (asymptomatic parasitemia is not treated per current Ugandan standard of care). Placental tissue was processed for histopathologic evidence of PM, as previously described (27 (link), 29 ), and placental blood and cord blood were tested for the presence of malaria parasites by both LAMP and microscopy.

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Odorizzi P.M., Jagannathan P., McIntyre T.I., Budker R., Prahl M., Auma A., Burt T.D., Nankya F., Nalubega M., Sikyomu E., Musinguzi K., Naluwu K., Kakuru A., Dorsey G., Kamya M.R, & Feeney M.E. (2018). In utero priming of highly functional effector T cell responses to human malaria. Science translational medicine, 10(463), eaat6176.

Publication 2018

LAMP kits

Blood Cord blood Lamp assays Malaria Maternal Microscopy Parasitemia Parasites Placental Pregnancy Tissue

Corresponding Organization : University of California, San Francisco

Other organizations : Stanford University, Infectious Diseases Research Collaboration, Makerere University

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Variable analysis

independent variables

Maternal malaria parasitemia assessed every 4 weeks throughout pregnancy, beginning at enrollment

dependent variables

Presence of malaria parasites in maternal peripheral blood
Histopathologic evidence of placental malaria (PM) in placental tissue
Presence of malaria parasites in placental blood and cord blood

control variables

Asymptomatic parasitemia is not treated per current Ugandan standard of care

positive controls

LAMP assays were batch analyzed at the end of the trial

negative controls

LAMP assays were not used to inform treatment

Annotations

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