Primary outcomes were the incidence of unruptured intracranial aneurysms and the rupture rate (number of mice with ruptured aneurysm/number of mice with ruptured or unruptured aneurysms). We used Fisher’s exact test for the analysis of primary outcomes. As an exploratory analysis, the survival analysis was performed using the Log-rank test. Mice that did not develop aneurysms were excluded in the survival analysis. Blood pressure and body weight were analyzed by ANOVA, followed by the Tukey-Kramer post hoc test. All of the results were expressed as mean ± SD. Statistical significance was considered at P < 0.05.