Patients with symptomatic PAD were included in this study if they met the following criteria: (1) a history of ambulatory leg pain; (2) ambulatory leg pain confirmed by treadmill exercise4 (link); and (3) an ABI≤0.908 (link) at rest or ≤0.73 after exercise.9 (link) Patients were excluded for the following conditions: (1) absence of PAD (ABI>0.90 at rest and ABI>0.73 after exercise); (2) noncompressible vessels (ABI≥1.40); (3) asymptomatic PAD; (4) use of medications indicated for the treatment of claudication (cilostazol or pentoxifylline) initiated within 3 months prior to investigation; (5) exercise limited by other diseases or conditions; (6) active cancer; (7) end‐stage renal disease defined as stage 5 chronic kidney disease; (8) abnormal liver function; and (9) failure to complete the baseline run‐in phase within 3 weeks. Patient flow in the study is shown in Figure .
Protocol detail
Evaluating Symptomatic Peripheral Artery Disease
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Abi 1
Cancer
Chronic kidney disease
Cilostazol
End stage renal disease
Medications
Pain
Patient
Pentoxifylline
Vessels
Corresponding Organization :
Other organizations : University of Oklahoma Health Sciences Center, Veterans Health Administration
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Variable analysis
independent variables
- History of ambulatory leg pain
- Ambulatory leg pain confirmed by treadmill exercise
- ABI≤0.90 at rest or ≤0.73 after exercise
- Not explicitly mentioned
- Absence of PAD (ABI>0.90 at rest and ABI>0.73 after exercise)
- Noncompressible vessels (ABI≥1.40)
- Asymptomatic PAD
- Use of medications indicated for the treatment of claudication (cilostazol or pentoxifylline) initiated within 3 months prior to investigation
- Exercise limited by other diseases or conditions
- Active cancer
- End-stage renal disease defined as stage 5 chronic kidney disease
- Abnormal liver function
- Failure to complete the baseline run-in phase within 3 weeks
- Not explicitly mentioned
- Not explicitly mentioned
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