Genome-wide Genotyping and Imputation

Genome-wide genotyping in the Fenland cohort was performed in three subcohorts with use of the Affymetrix Genome-Wide Human SNP Array 5.0, the Affymetrix UK Biobank Axiom Array, or the Illumina CoreExome-24 v1 BeadChip, with imputation to the Haplotype Reference Consortium v1.1 (42 (link)), the 1000 Genomes Project (43 (link)), and the UK10K (44 (link)) reference panels. Samples from EPIC-Norfolk and UK Biobank were genotyped with the Affymetrix UK Biobank Axiom Array and imputed to the same reference panels.

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Bowker N., Hansford R., Burgess S., Foley C.N., Auyeung V.P., Erzurumluoglu A.M., Stewart I.D., Wheeler E., Pietzner M., Gribble F., Reimann F., Bhatnagar P., Coghlan M.P., Wareham N.J, & Langenberg C. (2021). Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region. Diabetes, 70(11), 2706-2719.

Publication 2021

Genome-Wide Human SNP Array 5.0

Genome human Genomes Haplotype

Corresponding Organization : Berlin Institute of Health at Charité - Universitätsmedizin Berlin

Other organizations : MRC Biostatistics Unit, Wellcome/MRC Institute of Metabolic Science, Eli Lilly (United States)

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Variable analysis

independent variables

Genome-wide genotyping in the Fenland cohort
Genotyping of samples from EPIC-Norfolk and UK Biobank

dependent variables

Measured outcomes

control variables

Imputation to the Haplotype Reference Consortium v1.1, the 1000 Genomes Project, and the UK10K reference panels

controls

No positive or negative controls were explicitly mentioned in the input information.

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