Cardiac Perfusion Imaging with Doxorubicin

All CMR exams were performed before doxorubicin administration, using a 3 Tesla Philips Achieva Tx whole-body scanner (Philips Healthcare, Best, the Netherlands) equipped with a 32-element phased-array cardiac coil. Imaging studies were performed under the same anaesthesia used for doxorubicin administration. Cardiac quantitative perfusion was estimated using dynamic acquisition with dual-saturation recovery (TS=20, 80 ms) during gadolinium-based contrast administration (0.1 mmol/kg), as previously described.¹² (link) After perfusion map generation, regions of interest were analysed in the infused and remote areas using dedicated software (MR Extended Work Space 2.6, Philips Healthcare).