Intermittent Exotropia in Children

Parents gave written informed consent, and children gave written assent when required. The protocol was approved by the institutional review boards of the Mayo Clinic, Jaeb Center for Health Research, and other local sites involved in the study. Data were collected and analyzed in accordance with the Health Insurance Portability and Accountability Act guidelines.
The IXTQ was completed by 575 parents of 575 children aged 1 through 16 years with intermittent exotropia at the time of their child’s clinic examination, enrolled from May 15, 2008, through July 24, 2013. The 295 children aged 5 years or older completed the age-appropriate child IXTQ. Parents and children completed the IXTQ as part of routine care in the strabismus practice of one of the authors (J.M.H., n = 110) or at the enrollment examination for 1 of 2 ongoing randomized clinical trials being conducted by the Pediatric Eye Disease Investigator Group (NCT 01032603 [n = 69] and NCT 01032330 [n = 396]). Child questionnaires were administered to children aged 5 through 7 years by study personnel. All 8- to 17- year-old child, proxy, and parent questionnaires were self-administered. Patient demographics are reported in eTable 1 in the Supplement.

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Leske D.A., Holmes J.M, & Melia B.M. (2015). Evaluation of the Intermittent Exotropia Questionnaire Using Rasch Analysis. JAMA ophthalmology, 133(4), 461-465.

Publication 2015

Child Clinic examination Exotropia Eye disease Institutional review boards Parent Patient Strabismus Supplement

Corresponding Organization :

Other organizations : Mayo Clinic, WinnMed, Baylor College of Medicine, Vanderbilt University, Eastern Virginia Medical School, Illinois College of Optometry, Duke University, Wake Forest University, Emory University, University of Alabama at Birmingham, Marshall B. Ketchum University, University of Miami, University of Minnesota System, University of Florida, Lurie Children's Hospital, Queen's University, University at Albany, State University of New York, Medical University of South Carolina, Greater Baltimore Medical Center, Oregon Health & Science University, Salus University, Boston University, University of Houston, Mercy Hospital, Children's Mercy Hospital, Yeshiva University, Johns Hopkins University, Pacific University Oregon, University of Rochester, University of California, Davis, Cleveland Clinic, University of South Carolina, University of Iowa, University of Indianapolis, Indiana University – Purdue University Indianapolis, The Ohio State University, University of Wisconsin–Madison, Tufts University, Boston Children's Hospital, Boston Children's Museum, Scripps Health, Icahn School of Medicine at Mount Sinai, University of California, Los Angeles, Philadelphia University, University of Pennsylvania, Nova Southeastern University, University at Buffalo, State University of New York, Harvard University Press

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Variable analysis

independent variables

Intermittent exotropia in children aged 1 through 16 years

dependent variables

Responses on the Intermittent Exotropia Questionnaire (IXTQ) completed by parents and children

control variables

Parental written informed consent
Children's written assent (when required)
Approval by institutional review boards of the Mayo Clinic, Jaeb Center for Health Research, and other local sites involved in the study
Data collection and analysis in accordance with the Health Insurance Portability and Accountability Act guidelines

positive controls

Not explicitly mentioned

negative controls

Not explicitly mentioned

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