Moxifloxacin-Excipient Interaction Analysis

To analyze the possible interaction of Moxifloxacin (Mox) with formulation excipients, pure Mox, drug excipients (Cholestrol), synthesized amphiphilic molecule (DC-Met-10), and drug-loaded niosomal formulations (Mox-Met-Lip, SUL-Met-Lip, and empty vesicle (Met-Lip)) were mixed with a KBr disc and pressed to form a self-supporting disk. Spectra were scanned in the range of 400–4000 cm⁻¹ with an IR-470 spectrometer (Shimadzu, Kyoto, Japan) [7 (link)].

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Akbar N., Gul J., Siddiqui R., Shah M.R, & Khan N.A. (2021). Moxifloxacin and Sulfamethoxazole-Based Nanocarriers Exhibit Potent Antibacterial Activities. Antibiotics, 10(8), 964.

Publication 2021

IR-470 spectrometer

Drug excipients Moxifloxacin

Corresponding Organization : University of Sharjah

Other organizations : American University of Sharjah, International Center for Chemical and Biological Sciences, University of Karachi

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Variable analysis

independent variables

Pure Mox
Drug excipients (Cholestrol)
Synthesized amphiphilic molecule (DC-Met-10)
Drug-loaded niosomal formulations (Mox-Met-Lip, SUL-Met-Lip, and empty vesicle (Met-Lip))

dependent variables

Interaction of Moxifloxacin (Mox) with formulation excipients

control variables

KBr disc
IR-470 spectrometer (Shimadzu, Kyoto, Japan)
Spectral range of 400–4000 cm^-1

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