Quantifying Abdominal Adiposity and Liver Fat via MRI

MRI-examinations were performed to determine liver fat content (LFC) and volumes of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) as previously described (29 (link)). All exams were performed using 1.5 T clinical MRI-systems from Philips Medical System (Netherlands) after a light meal and in close proximity to the OGTT. Water-fat imaging techniques were used throughout. The scans were done over 16 cm along the craniocaudal axis and centered on the L1 vertebra. The adipose tissue volumes were determined using a fully automated segmentation method that uses a filtering technique to separate VAT from SAT. Liver fat image reconstruction was done by a multi-resolution version of a method that employs a whole-image optimization approach (30 (link)). A single operator trained by an experienced radiologist performed the measurements by manual segmentation in the axial slices of the water images using the software ImageJ (version 1.42q, http://rsbweb.nih.gov/ij/).

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Mörwald K., Aigner E., Bergsten P., Brunner S.M., Forslund A., Kullberg J., Ahlström H., Manell H., Roomp K., Schütz S., Zsoldos F., Renner W., Furthner D., Maruszczak K., Zandanell S., Weghuber D, & Mangge H. (2020). Serum Ferritin Correlates With Liver Fat in Male Adolescents With Obesity. Frontiers in Endocrinology, 11, 340.

Publication 2020

1.5 T clinical MRI-systems

Abdominal adipose tissue Axis Examinations Light Liver Ogtt Radiologist Scans Subcutaneous adipose tissue Vertebra Visceral adipose tissue

Corresponding Organization : Paracelsus Medical University

Other organizations : Uppsala University, University of Luxembourg, Salzburger Landeskliniken, Medical University of Graz

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Liver fat content (LFC)
Volumes of abdominal visceral adipose tissue (VAT)
Volumes of subcutaneous adipose tissue (SAT)

control variables

Measurements were performed using 1.5 T clinical MRI-systems from Philips Medical System (Netherlands)
Scans were done over 16 cm along the craniocaudal axis and centered on the L1 vertebra
Exams were performed after a light meal and in close proximity to the OGTT
Water-fat imaging techniques were used throughout
A single operator trained by an experienced radiologist performed the measurements by manual segmentation in the axial slices of the water images using the software ImageJ (version 1.42q)

controls

No positive or negative controls were explicitly mentioned in the provided information.

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