Protein biomarker measurements were conducted at the UK Dementia Research Institute biomarker laboratory as previously published (Chouliaras et al., 2022 (link)). In brief, commercially available Single molecule array (Simoa) assays were used to measure plasma Aβ40, Aβ42, Aβ40/42, GFAP, NfL and p-tau181 concentrations on an HDx instrument (Quanterix, Billerica, MA).
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