We retrospectively reviewed the medical records of consecutive patients with RB between 2006 and 2015 at 29 Chinese treatment centers over a 10-year period. Patients who had experienced trauma before the diagnosis of RB were selected and studied in further detail. This study adhered to the principles of the Declaration of Helsinki. Ethics Committee approval was obtained from Beijing Children’s Hospital. Signed informed consent was obtained from all of the children’s parents.
The collected patient data included age at initial trauma occurrence, sex (male, female), RB laterality (unilateral, bilateral), and heredity (sporadic, familial). The primary clinical presentation, diagnosis, and management before RB was suspected were also analyzed. Additionally, the site of trauma was noted. Intraocular RB staging at the time of detection was applied based on the International Classification of Intraocular Retinoblastoma (IIRC).[11 ] The interval between trauma occurrence and RB diagnosis was also calculated. Histopathological details of the enucleated eye were noted. Treatment outcomes (alive/dead) were recorded. The development of orbital recurrence or distant metastasis was recorded during the follow-up period.
For the statistical analyses, we used a statistical software package (SPSS version 22.0 IBM-SPSS, Chicago, IL). We first described the distribution of the main parameters by calculating their median or mean and standard deviation. We compared the assessed parameters between the two groups using the Student’s t-test or Mann–Whitney U test. Frequencies were compared using the chi-square test. The enucleation-free survival was determined using the Kaplan–Meier method and compared using the log-rank test. A P-value of < 0.05 was considered to be statistically significant.
The collected patient data included age at initial trauma occurrence, sex (male, female), RB laterality (unilateral, bilateral), and heredity (sporadic, familial). The primary clinical presentation, diagnosis, and management before RB was suspected were also analyzed. Additionally, the site of trauma was noted. Intraocular RB staging at the time of detection was applied based on the International Classification of Intraocular Retinoblastoma (IIRC).[11 ] The interval between trauma occurrence and RB diagnosis was also calculated. Histopathological details of the enucleated eye were noted. Treatment outcomes (alive/dead) were recorded. The development of orbital recurrence or distant metastasis was recorded during the follow-up period.
For the statistical analyses, we used a statistical software package (SPSS version 22.0 IBM-SPSS, Chicago, IL). We first described the distribution of the main parameters by calculating their median or mean and standard deviation. We compared the assessed parameters between the two groups using the Student’s t-test or Mann–Whitney U test. Frequencies were compared using the chi-square test. The enucleation-free survival was determined using the Kaplan–Meier method and compared using the log-rank test. A P-value of < 0.05 was considered to be statistically significant.
Free full text: Click here
