Gemcitabine Pharmacogenomics: SNP-SNP Interactions

SNP-SNP interactions of 21 non-synonymous SNPs in 9 genes involved in gemcitabine transport, metabolism and activity were deduced in silico as reported previously [12 (link)]. Briefly, Fisher’s exact probability test was used to show that POLA + 1747 GG/GA SNP (rs487989) was the most statistically significant SNP to be associated with mortality. Chi-squared test was employed to assess the association between POLA + 1747 GG/GA SNP and SLC28A2 + 65 CC SNP, which confirmed that this SNP pair gave the best survival outcome [12 (link)]. All statistical tests were two-sided and performed using SPSS software version 14.0 (SPSS Inc., Chicago, IL). Differences were considered statistically significant when the p-value was less than 0.05.