Approximately 150 MBq of 18F-DOPA was administered by bolus intravenous injection 30 s after the start of the PET imaging.
All the participants were asked not to eat or drink (except water), and refrain from alcohol for 12 h before the scan. In study 2, the imaging data were obtained on a Siemens CTI ECAT HR 962 PET scanner (Siemens, Erlanger, Germany) in three-dimensional mode. One hour before the scan, the participants received 400 mg Entacapone, a peripheral catechol-0-methyl-transferase inhibitor, and 150 mg Carbidopa, a peripheral aromatic acid decarboxylase inhibitor, to increase specific signal detection, as these compounds decrease the formation of radiolabeled metabolites that may cross the blood–brain barrier.43 (link) The participants were positioned in the scanner with the orbitomeatal line parallel to the transaxial plane of the tomograph. The head position was marked and monitored and the movement was minimized using a head strap.
The PET data were acquired in 32 frames of increasing duration over the 95 min scan (frame intervals: 8 × 15 s, 3 × 60 s, 5 × 120 s frames, 16 × 300 s).
All the participants were asked not to eat or drink (except water), and refrain from alcohol for 12 h before the scan. In study 2, the imaging data were obtained on a Siemens CTI ECAT HR 962 PET scanner (Siemens, Erlanger, Germany) in three-dimensional mode. One hour before the scan, the participants received 400 mg Entacapone, a peripheral catechol-0-methyl-transferase inhibitor, and 150 mg Carbidopa, a peripheral aromatic acid decarboxylase inhibitor, to increase specific signal detection, as these compounds decrease the formation of radiolabeled metabolites that may cross the blood–brain barrier.43 (link) The participants were positioned in the scanner with the orbitomeatal line parallel to the transaxial plane of the tomograph. The head position was marked and monitored and the movement was minimized using a head strap.
The PET data were acquired in 32 frames of increasing duration over the 95 min scan (frame intervals: 8 × 15 s, 3 × 60 s, 5 × 120 s frames, 16 × 300 s).
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