Intraindividual Response to Low-Sodium Diet

To examine the underlying mechanism of intraindividual response to a low-sodium diet, a randomized, controlled study will be conducted in a sample of 40 patients with hypertension aged >40 years. Children are thought to have minimal levels of high BP; therefore, we will only recruit adults. Participants will be asked to own their own smartphone for using mobile apps during the study. Our exclusion criteria are clinic BP of <140 mm Hg; estimated glomerular filtration rate of <15 mL/min/1.73 m² or on dialysis; history of organ transplantation; cardiovascular event, procedure or hospitalization for unstable angina/chronic heart failure within last 6 months; life expectancy of <1 year or a cancer diagnosis and treatment within the past 1 year that, in the judgment of clinical study staff, would compromise participant’s ability to comply with the protocol and complete the trial; active alcohol or substance abuse within the last 12 months; residence in a nursing home; diagnosis of dementia, treatment with medications for dementia; and unwilling or unable to participate in either of the interventions.