The following data were collected: demographic information, comorbidities, complications, D-dimer level, Simplified Acute Physiology Score (SAPS III), Sequential Organ Failure Assessment (SOFA) score, PaO2/FiO2 ratio, Body Mass Index (BMI), comorbidities, and use of anticoagulants and vasopressors. SAPS III and SOFA scores considered for analysis were calculated at the Intensive Care Unit (ICU) admission. D-dimer levels were evaluated using the HemosIL HS-500 automated immunoassay (HemosIL® D-dimer HS 500, Instrumentation Laboratory, 80003610270, Instrumental Laboratory Company, Bedford, MA, USA).
Comorbidities were assessed, including immunosuppression, arterial hypertension, diabetes, obesity, smoking, alcohol consumption, and neurological, hematological, respiratory, and cardiovascular diseases. Furthermore, immunosuppression was defined as a history of organ transplantation, chronic kidney disease, HIV infection, AIDS, and cancer treatment.
Clinical data included arterial blood gas analysis before and after the first prone session. In addition, the time until the first prone positioning, duration of the first prone session (in hours), number of prone sessions, and complications related to prone positioning were also collected. The time between the first intubation and the prone session was considered the first prone position. Unfortunately, due to hospital bed overload, it was impossible to collect data for blood gas analysis from the health staff on time. Therefore, the data considered for the analysis were obtained closest to the beginning and end of the first prone session.
Ventilator settings and respiratory mechanics calculations, such as Driving Pressure (DP), Plateau Pressure (Pplat), and respiratory system static Compliance (Cst), were collected before and after the first prone session. The total duration of the first prone session and a number of prone cycles were recorded. Furthermore, adverse effects, such as decreased oxygenation level, accidental extubation, central venous or arterial line removal, hemodynamic instability, acute arrhythmia, cardiopulmonary arrest, and vomiting, were recorded. Patient outcomes, including duration of invasive mechanical ventilation, length of hospital and ICU stay, reintubation, and survival, were also recorded.
Comorbidities were assessed, including immunosuppression, arterial hypertension, diabetes, obesity, smoking, alcohol consumption, and neurological, hematological, respiratory, and cardiovascular diseases. Furthermore, immunosuppression was defined as a history of organ transplantation, chronic kidney disease, HIV infection, AIDS, and cancer treatment.
Clinical data included arterial blood gas analysis before and after the first prone session. In addition, the time until the first prone positioning, duration of the first prone session (in hours), number of prone sessions, and complications related to prone positioning were also collected. The time between the first intubation and the prone session was considered the first prone position. Unfortunately, due to hospital bed overload, it was impossible to collect data for blood gas analysis from the health staff on time. Therefore, the data considered for the analysis were obtained closest to the beginning and end of the first prone session.
Ventilator settings and respiratory mechanics calculations, such as Driving Pressure (DP), Plateau Pressure (Pplat), and respiratory system static Compliance (Cst), were collected before and after the first prone session. The total duration of the first prone session and a number of prone cycles were recorded. Furthermore, adverse effects, such as decreased oxygenation level, accidental extubation, central venous or arterial line removal, hemodynamic instability, acute arrhythmia, cardiopulmonary arrest, and vomiting, were recorded. Patient outcomes, including duration of invasive mechanical ventilation, length of hospital and ICU stay, reintubation, and survival, were also recorded.
Free full text: Click here
