Protocol detail

Emory-Georgia Tech Health Discovery Cohort

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The replication cohort in Atlanta is the Center for Health Discovery and Well Being (CHDWB) cohort of the Emory-Georgia Tech Predictive Health Institute [21 (link)]. Whole genome genotypes were imputed from either Illumina OmniQuad or Illumina Core+Exome genotyping arrays using Impute2 against the 1000 Genomes. Over 200 trait measures are available for the cohort, at baseline and between 3 and 5 subsequent visits over a 4 year period (n = 738). Participants are all employees of Emory University between the ages of 25 and 75 contacted at random and representing a broad cross-section of the geography of the city of Atlanta and socioeconomic diversity. Summarised clinical data for the seven major traits is available (S4 Table). Written informed consent for participation in genetic research was provided under the auspices of the Institutional Review Boards of Georgia Tech and Emory University.

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Benton M.C., Lea R.A., Macartney-Coxson D., Hanna M., Eccles D.A., Carless M.A., Chambers G.K., Bellis C., Goring H.H., Curran J.E., Harper J.L., Gibson G., Blangero J, & Griffiths L.R. (2015). A Phenomic Scan of the Norfolk Island Genetic Isolate Identifies a Major Pleiotropic Effect Locus Associated with Metabolic and Renal Disorder Markers. PLoS Genetics, 11(10), e1005593.

Publication 2015

OmniQuad Core+Exome

Exome Genomes Institutional review boards Replication

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Variable analysis

independent variables

Whole genome genotypes were imputed from either Illumina OmniQuad or Illumina Core+Exome genotyping arrays

dependent variables

Over 200 trait measures are available for the cohort, at baseline and between 3 and 5 subsequent visits over a 4 year period

control variables

Participants are all employees of Emory University between the ages of 25 and 75 contacted at random and representing a broad cross-section of the geography of the city of Atlanta and socioeconomic diversity.

controls

Written informed consent for participation in genetic research was provided under the auspices of the Institutional Review Boards of Georgia Tech and Emory University.

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