Six Amish individuals between the ages of 11 and 29 with KRD (three female, three male) were psychometrically assessed using the Wechsler Intelligence Scale for Children 4th Edition (WISC-IV) (6–16 years) or the Wechsler Adult Intelligence Scale 4th Edition (WAIS-IV) (over 16 years), which assesses cognitive performance in four domains including verbal comprehension (VCI), perceptual reasoning (PRI), processing speed (PSI) and working memory (WMI) indices, and can be combined to generate a full-scale intelligence quotient (FSIQ) score. Further details are provided in the Supplementary material, ‘Methods’ section.
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