MRI-Derived Morphometric Analysis

Structural images were acquired on a General Electric MR750 3.0-Tesla MR scanner with a 12-channel head coil. We acquired 1 T1-weighted 3-dimensional Magnetization Prepared-Rapid Gradient Echo scan per participant (scanning parameters: repetition time (TR)/echo time (TE) 7,312/3.02 ms, flip angle 11°, 256 × 256 matrix, 1.2-mm thick, 196 sagittal slices, field of view = 270). Cortical thickness, surface area, volume, and local gyrification index as well as subcortical volumes were quantified using FreeSurfer 6.0.0 (http://surfer.nmr.mgh.harvard.edu). The procedure has been described in detail elsewhere (64 (link)–68 (link, link, link, link)). Smoothing was performed with a 10-mm kernel at full width/half max (FWHM) for cortical thickness, surface area, and volume. As local gyrification index already is a smooth measure, we only applied a 5-mm FWHM kernel for smoothing.

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Mackes N.K., Golm D., Sarkar S., Kumsta R., Rutter M., Fairchild G., Mehta M.A, & Sonuga-Barke E.J. (2020). Early childhood deprivation is associated with alterations in adult brain structure despite subsequent environmental enrichment. Proceedings of the National Academy of Sciences of the United States of America, 117(1), 641-649.

Publication 2020

MR750 3.0-Tesla MR scanner 12-channel head coil

Cortical Echo Electric Head

Corresponding Organization :

Other organizations : King's College London, University of Southampton, University College London, Ruhr University Bochum, University of Bath, Aarhus University

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Cortical thickness
Surface area
Volume
Local gyrification index
Subcortical volumes

control variables

General Electric MR750 3.0-Tesla MR scanner with a 12-channel head coil
Repetition time (TR) = 7,312 ms
Echo time (TE) = 3.02 ms
Flip angle = 11°
Matrix size = 256 x 256
Slice thickness = 1.2 mm
Number of sagittal slices = 196
Field of view = 270 mm
FreeSurfer 6.0.0 software used for quantification

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