Normality of data was checked using histogram, Kurtosis Skewness test, and Shapiro-Wilk test. For continuous variables with normal and non-normal distribution, mean (SD) and median (interquartile range) were used respectively. For categorical variables, the percentage of frequency was used. Student t-test and Mann–Whitney U-test were applied for continuous data which showed normal and non-normal distribution respectively. The categorical data was compared using the chi-square test. Fisher exact test was used instead, when the expected values in any of the cells of a contingency table were < 5. A P value of less than 0.05 was considered statistically significant. All analyses were conducted using STATA version 15.0 (Stata Corporation, College Station, TX, USA).
Sample size calculation was based on the mean amount of phenylephrine required for maintaining maternal hemodynamics during elective cesarean section under spinal anesthesia which was 501 (154) μg in parturients receiving glycopyrrolate as compared to 552 (118) μg in those who did not receive glycopyrrolate [9 (link)]. To detect this difference, we needed 114 subjects in each group with a power of 80%, at a two-sided alpha level of 0.05. Allowing for a 15% dropout rate during the study period, a total of 258 patients were enrolled (STATA version 15.0, Stata Corporation, College Station, TX, USA).
Sample size calculation was based on the mean amount of phenylephrine required for maintaining maternal hemodynamics during elective cesarean section under spinal anesthesia which was 501 (154) μg in parturients receiving glycopyrrolate as compared to 552 (118) μg in those who did not receive glycopyrrolate [9 (link)]. To detect this difference, we needed 114 subjects in each group with a power of 80%, at a two-sided alpha level of 0.05. Allowing for a 15% dropout rate during the study period, a total of 258 patients were enrolled (STATA version 15.0, Stata Corporation, College Station, TX, USA).
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