Protocol detail

Cocaine, Phenmetrazine, and Norbinaltorphimine Preparation

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For behavior, Cocaine HCl (National Institute on Drug Abuse Drug Supply Program, Bethesda, MD) and phenmetrazine hemifumarate (RTI International, Research Triangle Park, NC) were dissolved in sterile saline; norbinaltorphimine (nBNI) was dissolved in sterile injectable water. For fast-scan cyclic voltammetry, the KOR agonist U50,488 (National Institute on Drug Abuse Drug Supply Program, Bethesda, MD) and Cocaine HCl were dissolved in deionized water.

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Estave P.M., Albertson S.E., Karkhanis A.N, & Jones S.R. (2024). Co-targeting the kappa opioid receptor and dopamine transporter reduces motivation to self-administer cocaine and partially reverses dopamine system dysregulation. Scientific Reports, 14, 6509.

Publication 2024

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Variable analysis

independent variables

Cocaine HCl
Phenmetrazine hemifumarate
Norbinaltorphimine (nBNI)
U50,488

dependent variables

Not explicitly mentioned

control variables

Sterile saline
Sterile injectable water
Deionized water

positive controls

Not specified

negative controls

Not specified

Annotations

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