Metabolomic Profiling and Sodium Reduction

The aims of this clinical trial are to (1) determine the feasibility and preliminary efficacy of delivering a low-sodium diet intervention focused on changes in metabolomic profiling and reduction of urinary sodium level and BP in patients with hypertension; (2) examine the associations of urine metabolites with urinary sodium levels and BP control based on the hypothesis that targeted urine metabolites will have significant associations with urinary sodium level and differences in systolic BP (SBP) and diastolic BP (DBP).

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Ko J., Wang J., Chung M.L, & Sharma K. (2023). Examining the Individual Response to a Low-Sodium Diet in Patients with Hypertension: Protocol for a Pilot Randomized Controlled Trial. JMIR Research Protocols, 12, e39058.

Publication 2023

Diastolic bp Hypertension Low sodium diet Patients Sodium Systolic bp Urinary

Corresponding Organization : The University of Texas Health Science Center at San Antonio

Other organizations : Florida State University, University of Kentucky

Top 5 similar protocols

Variable analysis

independent variables

Low-sodium diet intervention

dependent variables

Metabolomic profiling
Urinary sodium level
Systolic blood pressure (SBP)
Diastolic blood pressure (DBP)

control variables

Control variables not explicitly mentioned

controls

No positive or negative controls specified

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