Lipid-based nanoparticle formulation

ADU-S100 was purchased from Chemietek (Indianapolis, IN, USA) and cyclic AMP (cAMP) was purchased from Cayman Chemical (Ann Arbor, MI, USA). All of the following lipids were purchased from Avanti Polar Lipids (Alabaster, AL, USA): 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt) (18:1 TAP (DOTAP)), hydrogenated soy L-α-phosphatidylcholine (HSPC), cholesterol, and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxyl (polyethylene glycol)-2000] (ammonium salt) (DSPE-PEG₂₀₀₀). All other chemicals were of analytical grade.

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Ji N., Wang M, & Tan C. (2023). Liposomal Delivery of MIW815 (ADU-S100) for Potentiated STING Activation. Pharmaceutics, 15(2), 638.

Publication 2023

ADU-S100

Alabaster Ammonium salt Cayman Chloride salt Cholesterol Cyclic amp Dotap Dspe peg2000 Lipids Phosphatidylcholine Phosphoethanolamine Polyethylene glycol 2000 Propane S100

Corresponding Organization :

Other organizations : University of Mississippi, University of Tennessee Health Science Center

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Variable analysis

independent variables

ADU-S100 purchased from Chemietek
Cyclic AMP (cAMP) purchased from Cayman Chemical
1,2-dioleoyl-3-trimethylammonium-propane (chloride salt) (18:1 TAP (DOTAP)) purchased from Avanti Polar Lipids
Hydrogenated soy L-α-phosphatidylcholine (HSPC) purchased from Avanti Polar Lipids
Cholesterol purchased from Avanti Polar Lipids
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxyl (polyethylene glycol)-2000] (ammonium salt) (DSPE-PEG₂₀₀₀) purchased from Avanti Polar Lipids

dependent variables

Not explicitly mentioned

control variables

All other chemicals were of analytical grade

controls

No positive or negative controls were explicitly mentioned

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