At enrolment, women were randomly assigned (1:1:1) to DMPA-IM, copper IUD or LNG implant.6 (link) Participants received an injection of 150 mg/mL DMPA-IM (Depo Provera; Pfizer, Puurs, Belgium) at enrolment and every 3 months until the final visit at 18 months after enrolment, a copper IUD (Optima TCu380A; Injeflex, Sao Paolo, Brazil) or a LNG implant (Jadelle; Bayer, Turku, Finland) at enrolment. Women returned for follow-up visits at 1 month after enrolment to address initial contraceptive side-effects and every 3 months thereafter, for up to 18 months with later enrolling participants contributing 12 to 18 months of follow-up. Visits included HIV serological testing, contraceptive counselling, syndromic STI management and safety monitoring.
Deese J., Philip N., Lind M., Ahmed K., Batting J., Beksinska M., Edward V.A., Louw C.E., Onono M., Palanee-Phillips T., Smit J.A., Baeten J.M., Donnell D., Mastro T.D., Mugo N.R., Nanda K., Rees H, & Morrison C. (2020). Sexually transmitted infections among women randomised to depot medroxyprogesterone acetate, a copper intrauterine device or a levonorgestrel implant. Sexually Transmitted Infections, 97(4), 249-255.
Contraceptive Contraceptive effects Copper iud Depo provera Dmpa Im injectionSafety Syndromic Women
Corresponding Organization : RTI International
Other organizations :
Columbia University, University of Washington, National Clinical Research, Setshaba Research Centre, University of the Witwatersrand, Aurum Institute, University of Pretoria, Kenya Medical Research Institute, Perinatal HIV Research Unit, Fred Hutch Cancer Center, Family Health International 360
Contraceptive method: DMPA-IM, copper IUD, or LNG implant
dependent variables
HIV serological testing
Contraceptive side-effects
Syndromic STI management
Safety monitoring
control variables
Contraceptive counselling
controls
Positive control: Not applicable
Negative control: Not applicable
Annotations
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