Dynamic Cerebral Blood Flow Imaging Protocol

The dynamic planar protocol (Fig. 1) was used as previously reported [14 (link)]. Dynamic frontal planar scans (2 s/frame, 60 frames, 3.9 mm/pixel) were acquired using a γ-camera (Siemens E.CAM, Siemens Medical Solutions, Erlangen, Germany) equipped with a low-energy high-resolution collimator from intravenous administration of a 167 MBq ¹²³I-IMP. The rest and stress data were acquired using the same γ-camera. Arterial blood samples were measured for γ-ray radiation counts using a well-type scintillation measurement device (NDW-351F; Hitachi Aloka Medical, Ltd.). The arterial blood samples were taken 10 min after the ¹²³I-IMP administration, and the input function values were obtained from the average of four measurements of radioactivity concentration per 1.0 g. To obtain stress data, 15 mg/kg of ACZ was injected intravenously 10 min before the administration of ¹²³I-IMP, and blood samples were collected under the same conditions as rest data. The image reconstruction method is filtered back projection, the reconstruction filter is ramp, and the preprocessing filter is Butterworth (cutoff 0.35 cycle/cm; order 8). Chang’s method was adopted for attenuation correction, and the attenuation coefficient was set to 0.07/cm. Scattering correction was not performed.Fig. 1

Protocol details (rest and stress)