Zoledronic Acid for Frail Elderly Bone Strengthening

The Zoledronic acid in frail Elders to STrengthen bone (ZEST) study was a 2-year double-blind, placebo-controlled, randomized clinical trial based in the Pittsburgh Pennsylvania area. Participants were enrolled and treated between December 2007 and March 2012 (ClinicalTrials.gov Identifier: NCT00558012).^{22 (link)}

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Greenspan S.L., Perera S., Ferchak M.A., Nace D.A, & Resnick N.M. (2015). Efficacy and Safety of Single Dose Zoledronic Acid for Osteoporosis in Frail Seniors: A Randomized Clinical Trial. JAMA internal medicine, 175(6), 913-921.

Publication 2015

Bone Frail elders Placebo Zoledronic acid

Corresponding Organization :

Other organizations : University of Pittsburgh

Top 5 similar protocols

Protocol cited in 5 other protocols

Variable analysis

independent variables

Zoledronic acid

dependent variables

Bone strength

control variables

Placebo

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