Multimodal Neuroimaging Protocols in Neurodegenerative Research

PET images were acquired using a Biograph mCT PET/CT scanner (Siemens Medical Solutions) in Seoul [11 (link)]; Discovery and Discovery MI PET scanners (GE medical systems) in BioFINDER 1 and 2, respectively [5 , 6 (link)]; a Biograph 6 Truepoint PET/CT scanner (Siemens Medical Solutions) for UCSF patients [18 (link)], a Siemens High-Resolution Research Tomograph (HRRT) scanner in PREVENT-AD [15 (link)], and across multiple scanners in the multi-center ADNI [27 (link)] and Avid Radiopharmaceuticals [7 (link)] cohorts. All PET data were locally reconstructed into 4 × 5-min frames for the 80–100-min ([¹⁸F]flortaucipir) and 70–90-min ([¹⁸F]RO948) intervals post-injection. MR images were acquired on a 3.0T Discovery MR750 scanner (GE medical systems) in Seoul [11 (link)], 3.0T Tim Trio or Skyra scanner (Siemens Medical Solutions) in BioFINDER [5 , 6 (link)], a 3.0T Tim Trio or Prisma scanner (Siemens Medical Solutions) at UCSF [18 (link)], a 3.0 Tim Trio scanner (Siemens Medical Solutions) in PREVENT-AD [15 (link)], and across multiple scanners in the multi-center ADNI [27 (link)] and Avid Radiopharmaceuticals [7 (link)] cohorts.

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Ossenkoppele R., Leuzy A., Cho H., Sudre C.H., Strandberg O., Smith R., Palmqvist S., Mattsson-Carlgren N., Olsson T., Jögi J., Stormrud E., Ryu Y.H., Choi J.Y., Boxer A.L., Gorno-Tempini M.L., Miller B.L., Soleimani-Meigooni D., Iaccarino L., La Joie R., Borroni E., Klein G., Pontecorvo M.J., Devous MD S.r., Villeneuve S., Lyoo C.H., Rabinovici G.D, & Hansson O. (2020). The impact of demographic, clinical, genetic, and imaging variables on tau PET status. European Journal of Nuclear Medicine and Molecular Imaging, 48(7), 2245-2258.

Publication 2020

Biograph mCT PET/CT scanner Discovery and Discovery MI PET scanners Biograph 6 Truepoint PET/CT scanner High-Resolution Research Tomograph (HRRT) scanner Discovery MR750 scanner 3.0T Tim Trio or Prisma scanner 3.0 Tim Trio scanner

Ct scanner Flortaucipir Frames Patients Prisma Radiopharmaceuticals Tomograph Trio

Corresponding Organization : Lund University

Other organizations : Gangnam Severance Hospital, Yonsei University, King's College London, Skåne University Hospital, University Memory and Aging Center, University of California, San Francisco, Roche (Switzerland), Douglas Mental Health University Institute, McGill University

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Variable analysis

independent variables

PET imaging using different scanners (Biograph mCT PET/CT, Discovery and Discovery MI PET, Biograph 6 Truepoint PET/CT, Siemens High-Resolution Research Tomograph (HRRT), and multiple scanners in ADNI and Avid Radiopharmaceuticals cohorts)
MRI imaging using different scanners (3.0T Discovery MR750, 3.0T Tim Trio or Skyra, 3.0T Tim Trio or Prisma, 3.0T Tim Trio, and multiple scanners in ADNI and Avid Radiopharmaceuticals cohorts)

dependent variables

Uptake of [18F]flortaucipir and [18F]RO948 PET tracers during specified post-injection intervals (80-100 min and 70-90 min, respectively)

control variables

All PET data were locally reconstructed into 4 × 5-min frames for the specified post-injection intervals

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