Clozapine N-oxide (CNO) dihydrochloride (Hello Bio) was dissolved in 0.9% saline and injected intraperitoneally 30 min before the start of the dark phase. Solutions were freshly prepared on each test day and doses were administered using a Latin square design. Animals received either 0, 5, or 10 mg/kg CNO per test day, based on previously reported CNO doses (Hart et al., 2018 (link); Panoz-Brown et al., 2018 (link)).
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