Post-Vaccination Antibody Response Study

This prospective observational study was performed using sera collected in February 2021 from 69 individuals without a previous SARS-CoV-2 infection in the course of a workplace vaccination campaign in the metropolitan area of Vienna, Austria. The samples were taken 21 ± 1 days (mean ± standard deviation) after the first dose of the Pfizer/BioNTech BNT162b2 vaccine. We included vaccinated persons rather than individuals with a history of SARS-CoV-2 infection, in order to be able to compare test systems following a more or less standardized stimulus. Further inclusion criteria were an age of >18 years, whereas an insufficient amount of serum resulted in exclusion from the study. The study protocol was reviewed and approved by the Ethics Committee of the Medical University of Vienna (EK1066/2021). All participants provided written informed consent to donate blood for the evaluation of diagnostic test systems (EK404/2012). The studied complied with the World Medical Association Declaration of Helsinki regarding ethical conduct of research involving human subjects.

Free full text: Click here

Perkmann T., Perkmann-Nagele N., Koller T., Mucher P., Radakovics A., Marculescu R., Wolzt M., Wagner O.F., Binder C.J, & Haslacher H. (2021). Anti-Spike Protein Assays to Determine SARS-CoV-2 Antibody Levels: a Head-to-Head Comparison of Five Quantitative Assays. Microbiology Spectrum, 9(1), 10.1128/spectrum.00247-21.

Publication 2021

BNT162b2 vaccine

Blood systems Bnt162b2 Diagnostic test Ethics committee Sars cov 2 infection Serum Vaccination campaign Vaccine

Corresponding Organization : Medical University of Vienna

Top 5 similar protocols

Protocol cited in 9 other protocols

Variable analysis

independent variables

Vaccination with the Pfizer/BioNTech BNT162b2 vaccine

dependent variables

Immune response (antibody levels)

control variables

Absence of prior SARS-CoV-2 infection
Age (>18 years)
Sufficient serum sample amount

controls

No positive or negative controls were explicitly mentioned.

Annotations

Based on most similar protocols

Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.

As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!