Tongue Xenografting for Lung Metastasis

Tongue xenografting and experimental lung metastasis experiments were performed as previously described (Goldie et al., 2012 (link)). Animal studies were subject to Cancer Research UK and King’s College London ethical review and performed in accordance with an approved UK Government Home Office license. A dox-rich diet (Harlan) was used to induce miR-203 expression in vivo. Bioluminescent imaging was conducted using a Xenogen IVIS 200 system (Perkin Elmer).

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Benaich N., Woodhouse S., Goldie S.J., Mishra A., Quist S.R, & Watt F.M. (2014). Rewiring of an Epithelial Differentiation Factor, miR-203, to Inhibit Human Squamous Cell Carcinoma Metastasis. Cell Reports, 9(1), 104-117.

Publication 2014

Xenogen IVIS 200 system

Animal Cancer Diet Ethical review Experimental lung Metastasis Tongue

Corresponding Organization :

Other organizations : Cancer Research UK, University of Cambridge, Cell Therapy Catapult, King's College London, Guy's Hospital, Otto-von-Guericke University Magdeburg

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Variable analysis

independent variables

Induction of miR-203 expression in vivo using a dox-rich diet

dependent variables

Tongue xenografting and experimental lung metastasis

control variables

Animal studies were subject to Cancer Research UK and King's College London ethical review and performed in accordance with an approved UK Government Home Office license

controls

Positive control: Not specified
Negative control: Not specified

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