Genetically Engineered Mice for Research

C57/B6 mice (8-week-old) were purchased from the Experimental Animal Center of the Kunming Institute of Zoology (China). The Mcam floxed mice (8-week-old) have been described previously^{30 (link)}. The MMTV-Cre (line D) and K14-Cre mice (8-week-old) were obtained from the Jackson Laboratory (USA). The female NOD/SCID mice (3-week-old) were purchased from the company of Charles River. The mice were raised in a specific pathogen free (SPF) environment with an ambient temperature of 18-22 °C, a humidity of 50%-60%, and a 12 h light-dark cycle. All experimental procedures and animal care and handling were performed according to the protocols approved by the Ethics Committee of the Kunming Institute of Zoology, Chinese Academy of Sciences (IACUC-RE-2023-07-006).