Thyroid Tumors Biorepository Analysis

Tumor samples were obtained from the Children’s Hospital of Philadelphia (CHOP) and Hospital for Sick Children, Toronto, Ontario, Canada. This study included archived Formalin-Fixed Paraffin-Embedded (FFPE) samples from 20 non-neoplastic thyroids, 8 adenomatous nodules and 60 sporadic well-differentiated follicular derived thyroid cancers (DTC): 47 PTCs and 13 FTCs. Demographic information including age and sex was collected from each patient in addition to histopathologic results and tumor staging. Ethics approvals for collection and use of the patient samples were obtained from the CHOP Institutional Review Board as part of the Child and Adolescent Thyroid Consortium (CATC) Biorepository study (IRB# 20-018240).

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Ricarte-Filho J.C., Casado-Medrano V., Reichenberger E., Spangler Z., Scheerer M., Isaza A., Baran J., Patel T., MacFarland S.P., Brodeur G.M., Stewart D.R., Baloch Z., Bauer A.J., Wasserman J.D, & Franco A.T. (2023). DICER1 RNase IIIb domain mutations trigger widespread miRNA dysregulation and MAPK activation in pediatric thyroid cancer. Frontiers in Endocrinology, 14, 1083382.

Publication 2023

Adenomatous Adolescent Child Embedded paraffin Formalin Ftcs Patient Ptcs Thyroid Thyroids neoplastic Tumor Well differentiated follicular cancers

Corresponding Organization : Philadelphia University

Other organizations : National Cancer Institute, Hospital for Sick Children

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Variable analysis

independent variables

Tumor samples from Children's Hospital of Philadelphia (CHOP) and Hospital for Sick Children, Toronto, Ontario, Canada

dependent variables

Histopathologic results
Tumor staging

control variables

20 non-neoplastic thyroids
8 adenomatous nodules
60 sporadic well-differentiated follicular derived thyroid cancers (DTC): 47 PTCs and 13 FTCs

controls

Positive control: 20 non-neoplastic thyroids
Negative control: 8 adenomatous nodules

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