Multidrug-Resistant Cancer Cell Lines

CEM human lymphoblastic leukemia cell line and its MDR variants, CEM/VLB_55–8, and CEM/VLB₁₀₀ [33 (link)], HeyA8 human ovarian cancer cell line and its MDR subline HeyA8-MDR, MCF-7 human breast cancer cell line and its MDR variant MCF7-MDR (originally named MCF-7/Adr) cells [34 (link)] were kindly provided by Dr. Fiedler (MD Anderson, TX, USA). 17-AAG and AUY922 were purchased from Enzo Life Sciences Inc. (Farmingdale, New York, USA) and Selleck Chemicals (Houston, TX, USA), respectively. EX527 was purchased from BioVision Inc. (Milpitas, CA, USA). Amurensin G, a natural SIRT1 inhibitor, was supplied Dr. Oh (Seoul National University, Seoul, Korea) as described previously [35 (link)].

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Kim H.B., Lee S.H., Um J.H., Oh W.K., Kim D.W., Kang C.D, & Kim S.H. (2015). Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1. Oncotarget, 6(34), 36202-36218.

Publication 2015

17-AAG AUY922 EX527

17 aag Amurensin g Auy922 Breast cancer Cell line Cells Human Human breast cancer Lymphoblastic leukemia Mcf7 Ovarian cancer Sirt1

Corresponding Organization : Pusan National University

Other organizations : Gachon University, Seoul National University

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Variable analysis

independent variables

17-AAG
AUY922
EX527
Amurensin G

dependent variables

The response of CEM human lymphoblastic leukemia cell line and its MDR variants (CEM/VLB_55–8, and CEM/VLB₁₀₀)
The response of HeyA8 human ovarian cancer cell line and its MDR subline HeyA8-MDR
The response of MCF-7 human breast cancer cell line and its MDR variant MCF7-MDR (originally named MCF-7/Adr)

control variables

Cell lines were kindly provided by Dr. Fiedler (MD Anderson, TX, USA)

controls

Positive control: Not specified
Negative control: Not specified

Annotations

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