Protocol detail

PiB PET Amyloid Imaging Protocol

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All participants in the Aim 2 analyses underwent a [¹¹C] Pittsburgh compound B (PiB) PET scan on a Siemens EXACT HR+ scanner; PiB processing and quantification methods are described in detail elsewhere (Johnson et al., 2014 (link)). A 70-min dynamic acquisition using reference Logan graphical analysis (cerebellum gray matter reference region) was used to estimate the PiB distribution volume ratio (DVR). A previously defined global DVR threshold of >1.19 (Sprecher et al., 2015 (link)) was used to dichotomize individuals as amyloid positive or negative (Aβ+/−).

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Mueller K.D., Du L., Bruno D., Betthauser T., Christian B., Johnson S., Hermann B, & Koscik R.L. (2022). Item-Level Story Recall Predictors of Amyloid-Beta in Late Middle-Aged Adults at Increased Risk for Alzheimer’s Disease. Frontiers in Psychology, 13, 908651.

Publication 2022

EXACT HR+ scanner

Amyloid Cerebellum gray matter Pet scan Pittsburgh compound b

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Variable analysis

independent variables

Not explicitly mentioned

dependent variables

PiB distribution volume ratio (DVR)

control variables

PiB PET scan on a Siemens EXACT HR+ scanner
PiB processing and quantification methods as described in Johnson et al., 2014
Reference Logan graphical analysis (cerebellum gray matter reference region) to estimate PiB DVR
Global DVR threshold of >1.19 (Sprecher et al., 2015) to dichotomize individuals as amyloid positive or negative (Aβ+/−)

positive controls

Not explicitly mentioned

negative controls

Not explicitly mentioned

Annotations

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